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2 End-Stage Degenerative Joint Disease A randomized, double-blind, parallel-group, active- and placebo-controlled, multiple-dose study evaluated the efficacy and safety of 50 mg and 75 mg NUCYNTA® given every 4 to 6 hours during waking hours for 10 days in patients aged 18 to 80 years, experiencing moderate to severe pain from end stage degenerative joint disease of the hip or knee, defined as a 3-day mean pain score of ≥5 on an 11-point pain intensity palexia scale, ranging from 0 to 10 .
Pain scores were assessed twice daily and assessed palexia the pain the patient had experienced over the previous 12 hours .
Patients were allowed to continue non-opioid analgesic therapy for which nucynta lol tapentadol controlled drug tapentadol (palexia) for moderate to severe acute pain they had been on a stable regimen before screening throughout the study .
Eighty-three percent (83%) of patients in the nucynta contraindications palexia and nausea tapentadol withdrawal tapentadol trade name nucynta tapentadol treatment groups and the placebo group took such analgesia during the study .
The 75 mg treatment group was dosed at 50 mg for the first day of the study, followed by 75 mg for the remaining nucynta like percocet nucynta yellow 50 nucynta kidney tapentadol drugs forum st john's wort and nine days .
Patients palexia requiring rescue analgesics other than study medication were discontinued for lack of efficacy .
Efficacy was evaluated by comparing the sum of pain intensity difference (SPID) versus placebo over the first five palexia days of treatment .
NUCYNTA® palexia 50 mg and 75 mg provided improvement in pain compared with placebo based on the 5-Day SPID .
For various degrees of improvement from baseline to the Day 5 endpoint, nucynta vs opana tapentadol for depression tapentadol hydrochloride solubility tapentadol nz palexia Figure 2 shows the fraction of patients achieving that level of improvement .

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